SHIMOKE, Koji |
|---|
Faculty, Department/Institute
- Faculty of Chemistry, Materials and Bioengineering Department of Life Science and Biotechnology
Academic status (qualification)
- Professor Apr. 1,2015
Undergraduate Degrees・University
- Kyushu University Faculty of Science1993 Graduated
Graduate Degrees・University
- Osaka University Doctor's Degree Program Biochemistry 1998 Completed
Academic Degrees
- Doctor(Sceince) Mar. 1998 Osaka University
Homepage Address, E-mail Address
- Homepage Address：http://neurobio.life-bio.kansai-u.ac.jp/
Research fields
| Research fields | keyword |
|---|---|
| Neurochemistry/Neuropharmacology | Neurotrophic factors;ER stress;Neurodegenarative disorders, PC12 cell line, Intracellular signaltransduction, apoptosis |
| Nerve anatomy/Neuropathology | |
| Molecular biology | apoptosis;endocrine disrupting properties;epigenetics |
| Neuroscience in general | bisphenol A; |
Research topics
| research topic | Prevension of ER stress-mediated apoptosis by neurotrophic factors |
|---|---|
| Study theme state | Individual Research |
| research duration | |
| Research Programs | Research Supported by Grants and Funding ( excluding National Institutions) |
| keyword | Neurotrophic factors,Trk-mediated,signaltransduction,Neurodegenerative disorders,cell survival,strategy for disorders,Autophagy,Epigenetic regulation |
| Research field | |
| Research Topics Overview |
| research topic | Promotion of apoptosis by artificial chemicals |
|---|---|
| Study theme state | Individual Research |
| research duration | |
| Research Programs | Research Supported by Grants and Funding ( excluding National Institutions) |
| keyword | apoptosis,endocrine disrupting properties,intracellular preventive mechanism,protein degradation pathway |
| Research field | |
| Research Topics Overview |
| research topic | |
|---|---|
| Study theme state | Joint research within Japan |
| research duration | |
| Research Programs | |
| keyword | epigenetics,histone modifications,neurons,signal transduction |
| Research field | |
| Research Topics Overview |
| research topic | Development of medicine for nervous system disorder by tegmina |
|---|---|
| Study theme state | Individual Research |
| research duration | |
| Research Programs | |
| keyword | natural material,tegmen,central nervous system |
| Research field | |
| Research Topics Overview | 甲虫は、変態を伴って成長する昆虫である。現在までに様々な甲虫の研究が進められているが、精神神経疾患の治療薬の開発を目的とした実験系は存在しない。本テーマでは、これまで社会性昆虫に分類されていない甲虫が変態の経た一過程で、社会性昆虫に酷似した生態を示すことを見出し、甲虫が自己の外へ放出し、その様な生態を示させる物質が精神神経疾患の治療薬として応用することを目的としている。 |
| research topic | |
|---|---|
| Study theme state | Individual Research |
| research duration | |
| Research Programs | |
| keyword | hypothalamus,synapse,nerve cell |
| Research field | |
| Research Topics Overview |
Intellectual Property Rights
- (Pending)
- application number：特願2009-136463 (Jun. 5,2009)
- (Pending)
- application number：特願2009-152924 (Jun. 5,2009)
- (Pending)
- application number：特願2010－2455306 (Nov. 1,2010)
- (Acquired)
- application number：特願2009-136463 (Jun. 5,2009)
- application number：特許第5309381号
Topics for Business-Government-Universities Joint Reserch
- Analysis of pro- or anti-apoptotic mechanism
Joint Projects/Commissioned Projects
- Analysis of the thrornboembolic infarction
2000 - 2009 Domestic Joint Research - Analysis of neurotrophic factors using cultured neurons and PC12 cells
2004 - 2014 Domestic Joint Research - Analysis of molecular mechanisms on neurodegenerative disorders via the endoplasmic reticulum stress-mediated apoptosis
2002 - 2014 International Joint Research
2010 - 2014 Domestic Joint Research
2013 - 2014 Domestic Joint Research
Research Publications
Academic presentationAnalysis of nurr1 gene expression and its downstream molecular mechanism on neurite outgrowth by class I HDAC inhibitors in PC12 cellsIn refereedOtherCo-authoredTAKAHASHI, Ryota;MARUOKA, Hiroki;SHIMOKE,Koji2019/12/3～2019/12/6Histone deacetylase (HDAC) inhibitors weaken the chromatin structure (heterochromatin) by inducing acetylation of specific lysine residues within histone proteins and increase gene expression. Thereby, they influence the proliferation or differentiation of various cells.
We have previously analyzed that valproic acid (VPA) and MS-275, Class I HDAC inhibitors, induce neurite extension in PC12 cells. However, it is unclear which hdac genes or what genes are responsible for neurite extension induced by HDAC inhibitors. In this study, we investigated the contribution of immediate early gene (IEG), nurr1, via the epigenetic expression mechanism to the neurite extension induced by using specific HDAC inhibitors.
International academic conferenceBisphenol A induces neurite extension in PC12 cellsIn refereedOtherCo-authoredSHIMOKE,Koji;MASTUURA, Kumi;MARUOKA, Hiroki2019/10/19～2019/10/2349th Annual Meeting of Socitety for NeuroscienceChicago, USABisphenol A (BPA) is included in plastics as a plasticizer widely. BPA is an endocrine disrupting chemical (EDC) that promotes a female-inducing phenotype in genital organs via estrogen receptors.
We have found that BPA and other alkylphenol compounds can cause apoptosis in PC12 cells when we add relatively high dose. This mechanism was classified as endoplasmic stress (ER)-mediated apoptosis due to involvement of accumulation of unfolded proteins with upregulation of glucose-regulated protein 78 (GRP78) / BiP (immunoglobulin heavy-chain binding protein), a marker of ER stress. In cell-based assays, we also discovered that BPA is an inducer of neurite outgrowth in PC12 cells when we add lower dose. Contrary to expectations, we also found that the neurites are unique compared with those induced by nerve growth factor (NGF). This suggests that BPA may have a direct function in differentiation of neurons. This evidence was obtained using neuronal marker proteins. In addition to formation of neurites in PC12 cells. A molecular analysis showed that acetylation of specific amino acids in histones, which induces expression of the orphan nuclear receptor nur77 gene, an immediate early gene, leading to epigenetic regulation of gene expression.
Academic presentationMolecular mechanism of nurr1 gene expression and its downstream target gene expression by class I HDAC inhibitors in PC12 cellsIn refereedOtherCo-authoredTAKAHASHI, Ryota;IDO, Daiki;YAMAZOE, Ryosuke;MARUOKA, Hiroki;SHIMOKE,Koji2019/9/18～2019/9/20
Academic presentationMolecular mechanism of nurr1 gene expression and its downstream target gene expression by VPA or MS-275 in PC12 cellsUnrefereedOtherCo-authorMARUOKA, Hiroki;TAKAHASHI, Ryota;YAMAZOE, Ryosuke;SHIMOKE,Koji2019/7/25～2019/7/28
PapersPossible neuronal toxin in plastics discarded in rivers and the oceanIn refereedAcademic JournalCo-authoredMATUURA, Kumi;MARUOKA, Hiroki;SHIMOKE,KojiClinical Pharmacology and Pharmaceutics2018/12～10.4172/2167-065X.1000187
Academic presentationIn refereedOtherCo-authoredTAKAHASHI, Ryota;IDO, Daiki;YAMAZOE, Ryosuke;MARUOKA, Hiroki;SHIMOKE,Koji2018/9～
Academic presentationIn refereedOtherCo-authoredYAMAZOE, Ryosuke;MARUOKA, Hiroki;SHIMOKE,Koji2018/9～
Academic presentationIn refereedOtherCo-authoredMATSUURA, Kumi;MARUOKA, Hiroki;SHIMOKE,Koji2018/9～
Academic presentationThe expression mechanism of nur77 gene and its downstream target gene in early stage of the forskolin-induced differentiation in PC12 cellsIn refereedOtherCo-authoredMARUOKA, Hiroki;YAMAZOE, Ryosuke;YATSUO, Keisuke;TAKAHASHI, Ryota;SHIMOKE,Koji2018/9～
Academic presentationIn refereedOtherCo-authoredYATSUO, Keisuke;FUCHIGAMI, Yuki;YAMAZOE, Ryosuke;SHIMOKE,Koji2017/12～
Academic presentationIn refereedOtherCo-authoredIDO, Daiki;TAKAHASHI, Ryota;YAMAZOE, Ryosuke;SHIMOKE,Koji2017/12～
Academic presentationBisphenol A attenuates neuronal differentiation in cerebral cortical neuronsIn refereedOtherCo-authoredMATSUURA, Kumi;YAMAZOE, Ryosuke;SHIMOKE,Koji2017/12～
International academic conferenceUpregulated expression of nur77 gene is important for neurite outgrowth induced by three HDAC inhibitorsIn refereedOtherCo-authoredYAMAZOE, Ryosuke;IDO, Daiki;YATSUO, Keisuke;GENKO, Soichiro;SHIMOKE,Koji2017/10～9th Annual Congress on Drug Design & Drug formulationSeoul, Korea
International academic conferenceUpregulated expression of nur77 gene is important for neurite outgrowth induced by three HDAC inhibitorsIn refereedOtherCo-authoredYAMAZOE, Ryosuke;IDO, Daiki;Yatsuo, Keisuke;GENKO, Soichiro;SHIMOKE,Koji2017/9～72nd Fujiwara seminarTomakomai, Japan
Academic presentationBisphenol A attenuates neuronal differentiation in cerebral cortical neuronsIn refereedOtherCo-authoredMATSUURA, Kumi;YAMAZOE, Ryosuke;MARUOKA, Hiroki;SHIMOKE,Koji2017/9～
PapersEpigenetic Regulation by Bisphenol A as a Neuronal MorphogenIn refereedAcademic JournalInternational coauthorshipMatsuura, Kumi;YAMAZOE, Ryosuke;MARUOKA, Hiroki;SHIMOKE, KojiJournal of Bioengineering and Biomedical Science7(4)2017/8～10.4172/2155-9538.1000e128
Academic presentationThe effect of forskolin on the differentiation of PC12 cells via the histone H3 acetylationIn refereedOtherCo-authoredIDO, Daiki;MARUYAMA, Hirohi;YAMAZOE, Ryosuke;YATSUO, Keisuke;SHIMOKE,Koji2017/5～
Academic presentationCo-author2016/9～
Academic presentationCo-author2016/5～
Academic presentationCo-author2016/5～
Academic presentationCo-author2016/5～
PapersEpigenetic Regulation: Neurite Outgrowth by Hormonal or Chemical Mechanisms in PC12 CellsUnrefereedAcademic JournalSingle-AuthorShimoke KJournal of Bioengineering and Biomedical Science6(5), 10001232016～
Academic presentationCo-author2015/12～
Academic presentationCo-author2015/12～
Academic presentationCo-author2015/12～
Academic presentationCo-author2015/12～
Academic presentationCo-author2015/9～
Academic presentationCo-author2015/9～
PapersGenomic control of upregulation of GRP78 expression for promotion of neurite elongation and attenuation of cell death via PKA-mediated signaling in PC12 cellsIn refereedAcademic JournalCo-authorYamazoe R;Nishihata Y;Nakagawa K;Aoyama H;Shimoke KClinical Pharmacology and Biopharmaceutics4(4), 150-1542015～
PapersEndocrine disrupting chemicals - inducers of epigenetic gene expression and enhancers of cell death in neuronsUnrefereedAcademic JournalSingle-AuthorShimoke KJournal of Bioengineering and Biomedical Sciences6(1), e1222015～
International academic conferenceInvolvement of specific nur77 family genes during neurite outgrowth induced by forskolin and a histone deacetylase inhibitor in PC12 cellsCo-authorShimoke K;Yamazoe R;Tomioka T;Tsumura K;Nisihata Y;Maruoka H;Ikeuchi T2015～45th Annual Meeting of Society for NeuroscienceChicago, USA
PapersThe histone deacetylase inhibitor trichostatin A induces neurite outgrowth in PC12 cells via the epigenetically regulated expression of the nur77 geneIn refereedAcademic JournalCo-authorTomioka T;Maruoka H;Kawa H;Yamazoe R;Fujiki D;Shimoke K;Ikeuchi TNeurosci. Res.88, 39-482014～
Academic presentationCo-author2014～
International academic conferenceTricostatin A induces neurite outgrowth via expression of Nur77 in PC12 cellsCo-authorShimoke K;Tomioka T;Aoyama H;Nishihata Y;Maruoka H;Ikeuchi T2014～World Congress on NeurotherapeuticsBasel, Switzerland
International academic conferenceHistone deacetyase inhibitor (K-350) promotes neurite outgrowth and cell survival via histone H3 modification in neuronsUnrefereedCo-author2013/11～43rd Annual Meeting of Society for NeuroscienceSan Diego, U.S.A.
PapersMechanisms of neurotrophic activities via low-molecular-weight compounds : post-transcriptional regulation in PC12 cells and neurons.In refereedAcademic JournalCo-author2013～
PapersHistone deacetylase inhibitor for neurodegenerative diseases: A possible medicinal strategy by prevention of ER stress-mediated apoptosis and neurite elongation.In refereedAcademic JournalCo-authorClinic. Pharmacol. BiopharmaceuticsS1, 004-0062013～
Academic presentationUnrefereedCo-author2013～
Academic presentationUnrefereedCo-author2013～
Academic presentationUnrefereedCo-author2013～
Academic presentationUnrefereedCo-author2013～
Academic presentationPrevention of tunicamycin-mediated apoptosis and induction of neurite by HDAC inhibitors in PC12 cellsUnrefereedCo-author2013～
Academic presentationUnrefereedCo-author2013～
Histone deacetylase inhibitor for neurodegenerative diseases: A possible medicinal strategy by induction of neurite outgrowthUnrefereedCo-author2013～8th International Symposium in Science and TechnologyKansai University, Osaka, Japan
Academic presentationCo-author2012/12～
International academic conferenceNew 2-aminobenzamide-type histone deacetyase inhibitor (K-350) promotes neurite outgrowth via histone H3 modification in PC12 cellsUnrefereedOtherCo-authorKoji Shimoke;Hiroki Maruoka;Ryo Hosokawa;Yoshiyuki Hirata;Hiromichi Kawa;Kouta Okamoto;Daichi Fujiki;Shinichi Uesato;Toshihiko Ikeuchi2012/11/13～2012/11/1742nd Annual Meeting of Society for NeuroscienceNew Orleans, U.S.A.
PapersNew Orally Bioavailable 2-aminobenzamide-type Histone Deacetyase Inhibitor Promotes Neurite Outgrowth via Histone H3 Modification in PC12 cells: a Possible Therapeutic Candidate for Neuronal DiseasesIn refereedAcademic JournalCo-authorMaruoka, H.;Hosokawa, R.;Hirata, Y.;Kawa, H.;Okamoto, K.;Waki, T.;Uesato, S.;Ikeuchi, T.;Shimoke, K.Journal of Bioengineering and Biomedical ScienceS5, 1-52012/11～
PapersApoptosis-inducing activity of endocrine-disrupting chemicals in cultured PC12 cellsIn refereedAcademic JournalCo-authorHarue Sasaya;Kazuya Yasuzumi;Hiroki Maruoka;Ayumi Fujita;Yuichi Kato;Taiki Waki;Koji Shimoke;Toshihiko IkeuchiAdvances in Biological Chemistry2, 92-1052012/5～
Academic presentationOrally bioavailable HDAC inhibitor K-350 promotes neurite outgrowth in PC12 cellsUnrefereedCo-authorKoji Shimoke;Ryo Hosokawa;Hiroki Maruoka;Yoshiyuki Hirata;Kouta Okamoto;Shinichi Uesato;Toshihiko Ikeuchi2012/5～
Research reportUnrefereedIn-house publicationCo-author2012/1～
PapersBioavailable 2-aminobenzamide-type Histone Deacetyase Inhibitor Promotes Neurite Outgrowth via Histone H3 Modification in PC12 cells: a Possible Therapeutic Candidate for Neuronal DiseasesIn refereedAcademic JournalCo-author2012～
Academic presentationEffect of HDAC inhibitors on neurite outgrowth and viability in PC12 cellsCo-authorOkamoto K;Maruoka H;Fujiki D;Hosokawa R;Hirata Y;Kawa H;Uesato S;Ikeuchi T;Shimoke K2012～
Academic presentationSubtype specific mechanisms of neurite outgrowth and cell survival by HDAC families in PC12 cellsUnrefereedCo-authorSugihara, K.;Maruoka, H.;Hosokawa, R.;Shimoke, K.;Ikeuchi, T.2011/12～
International academic conferenceNerve growth factor decreases ER stress-mediated apoptosis through refolding unfolded protein structure by glucose-regulated protein 78 in PC12 cellsUnrefereedCo-authorKoji Shimoke;Harue Sasaya;Hiroki Maruoka;Kensuke Sugihara;Michimasa Nobuhara;Toshihiko Ikeuchi2011/11～41th Annual Meeting of Society for NeuroscienceWashington.D.C., U.S.A.
Academic presentationUnrefereedCo-author2011/9～
Academic presentationUnrefereed2011/9～
Academic presentationForskolin suppresses ER stress-mediated apoptosis via enhanced expression of GRP78 by non-PI3-kinase pathway in PC12 cellsUnrefereedCo-authorAyumi Fujita;Yosuke Nakatani;Hiroki Maruoka;Michimasa Nobuhara;Kazuma Tarutani;Koji Shimoke;Toshihiko Ikeuchi2011/9～
Academic presentationCo-author2011/5/19～2011/5/20
Research reportCo-author2011/1～
BookAnalysis of the role of nerve growth factor in promoting cell survival during endoplasmic reticulum stress in PC12 cells.In refereedOtherCo-authorSHIMOKE Koji;SASAYA Harue;IKEUCHI ToshihikoMethods in Enzymology430, 53-702011～
PapersAppearance of nuclear-sorted caspase-12 fragments in cerebral cortical and hippocampal neurons in rats damaged by autologous blood clot embolic brain infarctions.In refereedAcademic JournalCo-authorSHIMOKE Koji;MATSUKI Yoshinori;FUKUNAGA Kenji;MATSUMURA Yoshinobu;FUJITA Eriko;SUGIHARA Kensuke;NOBUHARA Michimasa;MARUOKA Hiroki;IKEUCHI Toshihiko;KUDO MotoshigeCellular and Molecular Neurobiology31, 795–8022011～
PapersLow-molecular-weight compounds having neurotrophic activity in cultured PC12 cells and neuronsIn refereedAcademic JournalCo-authorMaruoka, H.;Sasaya, H.;Sugihara, K.;Shimoke, K.;Ikeuchi, T. Journal of Biochemistry150, 473-4752011～
PapersThe reparative time-course is not influenced by the size of lesions in embolic cerebral infarction in ratsIn refereedIn-house publicationCo-authorMatsuki, Y.;Shimoke, K.;Kuroda, M.;Kudo, M.Journal of Tokyo Medical University69, 473-4822011～
International academic conferenceNerve growth factor decreases the expression of PUMA and Bim during ER stress-mediated apoptosis in PC12 cellsCo-authorShimoke K;Nobuhara M;Sugihara K;Hosokawa R;Yasuzumi K;Okamoto K;Kawa H;Fujita A;Ikeuchi T2011～6th International Symposium in Science and TechnologyKansai University, Osaka, Japan
Academic presentationUnrefereedCo-author2010/12～
LectureUnrefereedSingle-Author2010/11～
International academic conferenceNerve growth factor decreases ER stress-induced apoptosis through down-regulation of PUMA and Bim expression in PC12 cells.Co-authorSHIMOKE Koji;KISHI Soichiro;NAKATANI Yosuke;IRIFUNE Hiromi;SUGIHSARA Kensuke;NOBUHARA Michimasa;SASAYA Harue;IKEUCHI Toshihiko2010/10～40th Annual Meeting of Society for NeuroscienceSan Diego, U.S.A.
Academic presentationThe control effect of NGF on autophagy induced by chloroquine and tunicamycin in PC12 cells.Co-authorIRIFUNE Hiromi;SHIMOKE Koji;SASAYA Harue;SUGIHARA Kensuke;NOBUHARA Michimasa;IKEUCHI Toshihiko2010/9～Neuro2010
Academic presentationAnalysis of mechanisms of neurite outgrowth and cell survival against ER stress by HDAC inhibitors in PC12 cells.Co-authorSUGIHARA Kensuke;MARUOKA Hiroki;NOBUHARA Michimasa;IRIFUNE Hiromi;NAKATANI Yosuke;SHIMOKE Koji;IKEUCHI Toshihiko2010/5～
Academic presentation2010/5～
PapersNerve growth factor attenuates 2-deoxy-d-glucose-triggered endoplasmic reticulum stress-mediated apoptosis via enhanced expression of GRP78Academic JournalCo-authorKishi S.;Shimoke K.;Nakatani Y.;Shimada T.;Okumura N.;Nagai K.;Shin-Ya K.;Ikeuchi T.Neuroscience Research66, 14-212010～English
PapersDibutyryl-cAMP up-regulates nur77 expression via histone modification during neurite outgrowth in PC12 cells.In refereedAcademic JournalCo-authorMARUOKA Hiroki;SASAYA Harue;SHIMAMURA Takafumi;NAKATANI Yosuke;SHIMOKE Koji;IKEUCHI ToshihikoJ. Biochem.148, 93-1012010～
Academic presentationAnalysis of GRP78 promoter region involved in NGF-induced up-regulation during suppression of ER stress-mediated apoptosis in PC12 cellsCo-authorYosuke Nakatani;Soichiro Kishi;Koji Shimoke;Takafumi Shimada;Hiromi Irifune;Harue Sasaya;Toshihiko Ikeuchi2009～English
Academic presentationBax oligomerization promotes ER stress-mediated apoptosis and nerve growth factor prevents it in PC12 cellsCo-authorTakafumi Shimada;Koji Shimoke;Soichiro Kishi;Hiromi Irifune;Yosuke Nakatani;Harue Sasaya;Toshihiko Ikeuchi2009～English
International academic conferenceNerve growth factor prevents ER stress-induced apoptosis via down-regulation of PUMA expression in PC12 cellsCo-authorKoji Shimoke;Takafumi Shimada;Soichiro Kishi;Hiromi Irifune;Yosuke Nakatani;Harue Sasaya;Toshihiko Ikeuchi2009～17th Euro-conference on apoptosisEuropean Cell Death Organization, Paris, FranceEnglish
International academic conferenceNerve growth factor enhances GRP78 expression only under the condition of ER stress in PC12 cellsCo-authorKoji Shimoke;Yosuke Nakatani;Soichiro Kishi;Takafumi Shimada;Hiromi Irifune;Harue Sasaya;Toshihiko Ikeuchi2009～39th Annual Meeting of Society for NeuroscienceChicago, U.S.A.English
PapersCaspase-3 activation and lipid peroxidation are important for apoptotic cell death in cerebral infarctionIn refereedIn-house publicationCo-authorShimoke K.;Yamazaki I.;Matsuki Y.;Ikeuchi T.;Kudo M.J. Tokyo Med. Univ.67, 15-212009～English
CommentaryPrevention of apoptosis by neurotrophic factors -Contribution of pathophysilogical analysis to therapy of neurodegenerative diseases-In-house publicationCo-author2009～
Research reportIn-house publicationCo-authorSHIMOKE,Koji;;SHIMOKE Koji2009～Japanese
Research reportIn-house publicationCo-author2009～
PapersProtection from ER stress-mediated apoptosis by the neurotrophinsIn refereedAcademic JournalCo-authorShimoke KojiCurr. Topic. Biochem. Res.11, 19-282009～
Academic presentationNerve growth factor promotes GRP78 expression only under the condition of ER stressCo-authorShimoke K;Nakatani Y;Kishi S;Shimada T;Irifune H;Sasaya H;Ikeuchi T2009～
OtherCo-author2008/3/4～
Papersp-Nonylphenol induces endoplasmic reticulum stress-mediated apoptosis in neuronally differentiated PC12 cellsIn refereedAcademic JournalCo-authorKusunoki T.;Shimoke K.;Komatsubara S.;Kishi S.;Ikeuchi TNeuroscience Letters431(3), 256-2612008～EnglishKansai University Research Grants 20070401-20080331
PapersBuilding an international network exchange program of education and research for graduate course students in life science and biotechnologyUnrefereedIn-house publicationCo-authorSHIMOKE KojiScience and Technology Reports of Kansai University50, 83-942008～EnglishKansai University Special Research Fund 20070401-20080331
Academic presentationNicotine suppresses tunicamycin-induced expression of GRP78 during ER stress-mediated apoptosis via preventing a common step upstream of Ire1-XBP1 and ATF6 pathways in PC12 cellCo-authorHarue Sasaya;Takahiro Utsumi;Koji Shimoke;Hitoshi Nakayama;Toshihiko Ikeuchi2008～English
Academic presentationNerve growth factor attenuates 2-deoxyglucose-triggered endoplasmic reticulum stress-mediated apoptosis via enhanced induction of GRP78 expressionCo-authorSoichiro Kishi;Koji Shimoke;Nobuaki Okumura;Takafumi Shimada;Yuko Fujita;Katsuya Nagai;Kazuo Shin-ya;Toshihiko IkeuchiBulletin of the Japanese Society for Neurochemistry47, 2312008～English
International academic conferenceHyperinduction of GRP78 expression by NGF-TrkA signaling promotes cell survival during ER stress-mediated apoptosis of PC12 cellCo-authorKoji Shimoke;Soichiro Kishi;Takafumi Shimada;Yuko Fujita;Nobuaki Okumura;Toshihiko Ikeuchi2008～38th Annual Meeting of Society for NeuroscienceWashington D.C., U.S.A.English
PapersER stress is the initial response to polyglutamine toxicity in PC12 cellsIn refereedAcademic JournalCo-authorHitoshi Nakayama;Masashi Hamada;Nobuhiro Fujikake;Yoshitaka Nagai;Jing Zhao;Osamu Hatano;Koji Shimoke;Minoru Isosaki;Masanori Yoshizumi;Toshihiko IkeuchiBiochem. Biophys. Res. Commun.377, 550-5552008～English
Apoptosis inducing chemicals in the environmentIn-house publicationCo-authorSHIMOKE,Koji;SHIMOKE Koji2008～
Research reportIn-house publicationCo-author2008～
Research reportIn-house publicationCo-author2008～
PapersNicotine suppresses tunicamycin-induced, but not thapsigargin-induced, expression of GRP78 during ER stress-mediated apoptosis in PC12 cellsAcademic JournalCo-authorSasaya H;Utsumi T;Shimoke K;Nakayama H;Matsumura Y;Fukunaga K;Ikeuchi TJ. Biochem.144, 251-2572008～
UnrefereedOtherCo-authorSHIMOKE,Koji;SHIMOKE Koji2007～Japanese
Research reportUnrefereedOtherCo-authorSHIMOKE,Koji;SHIMOKE Koji2007～
PapersOpposing mechanism of extracellular signal-regulated kinases on hydrogen peroxide-induced apoptosis in PC12 cellsIn refereedIn-house publicationCo-authorShimoke K.;Kudo M.;Ikeuchi T.J. Tokyo Med. Univ.65, 283-2892007～English
CommentaryUnrefereedIn-house publicationCo-author2007～Kansai University Research Grants 20070401-20080331
Academic presentationNerve growth factor attenuates 2-deoxyglucose-triggered endoplasmic reticulum stress-mediated apoptosis via up-regulation of GRP78 expressionCo-authorSoichiro Kishi;Masashi Hamada;Koji Shimoke;Kazuo Shin-ya;Yuko Fujita;Toshihiko Ikeuchi2007～English
Academic presentationNicotine suppresses tunicamycin-induced, but not thapsigargin-induced, expression of GRP78 during ER stress-mediated apoptosis in PC12 cellsCo-authorHarue Sasaya;Koji Shimoke;Soichiro Kishi;Yuko Fujita;Takafumi Shimada;Hitoshi Nakayama;Toshihiko Ikeuchi2007～English
Academic presentationModification of histone H3 during neurite outgrowth by cAMP in PC12 cellsCo-authorMaruoka H;Shimamura Y;Hamada M;Sasaya H;Kishi S;Shimoke K;Ikeuchi T2007～
Academic presentationImportance of up-regulated Bim expression during tunicamycin-induced ER stress-mediated apoptosis in PC12 cellsCo-authorShimoke K;Kishi S;Hamada M;Sasaya H;Fujita Y;Ikeuchi T2007～
Academic presentationEffects of proteasome inhibitor on tunicamycin-, thapsigargin-, and polyglutamine-induced ER stress and cell death in PC12 cellsCo-authorNakayama H;Hamada M;Zhao J;Shimoke K;Isosaki M;Satoh H;Yoshizumi M;Ikeuchi T2007～
International academic conferenceInvolvement of up-regulated Bim expression in tunicamycin-induced ER stress-mediated apoptosis of PC12 cellsCo-authorShimoke K;Komatsubara S;Kishi S;Hamada M;Sasaya H;Fujita Y;Ikeuchi T2007～37th Annual Meeting of Society for NeuroscienceSan Diego, U.S.A.
Academic presentationPolyglutamine-expanded YFP-induced ER stress-mediated apoptosis and its suppression by NGF in PC12 cellsCo-authorHamada M;Shimoke K;Kishi S;Nagai Y;Ikeuchi T2007～
Academic presentationEndocrine disrupting chemicals induce endoplasmic reticulum stress-mediated apoptosis in naive PC12 cellsCo-authorAndo K;Shimada T;Kishi S;Shimoke K;Ikeuchi T2007～
BookEndoplasmic reticulum stress-induced apoptosis and its prevention by neurotrophinsUnrefereedMonographCo-authorKoji Shimoke;Toshihiko Ikeuchi"New Trends in Brain Research"NOVA Science Publishers, Inc. (New York)61-742006～English
PapersSubtypes of neuronal nicotinic acetylcholine receptors involved in nicotine-induced phosphorylation of extracellular signal-regulated kinase in PC12h cells.In refereedAcademic JournalCo-authorNakayama H.;Shimoke K.;Kishi S.;Sasaya H.;Ikeuchi T.Neuroscience Letters392, 101-1042006～English
PapersSynthesis and cancer antiproliferative activity of new histone deacetylase inhibitors: hydrophilic hydroxamates and 2-aminobenzamide-containing derivativesIn refereedAcademic JournalCo-authorNagaoka Y;Maeda T;Kawai Y;Nakashima D;Oikawa T;Shimoke K;Ikeuchi T;Kuwajima H;Uesato S.Eur. J. Med. Chem.41(6), 697-7082006～EnglishKansai University Special Research Fund
Academic presentationMolecular mechanism of polyglutamine-expanded YFP-mediated ER stress in PC12 cellsCo-authorMasashi Hamada;Hitoshi Nakayama;Soichiro Kishi;Yoshitaka Nagai;Koji Shimoke;Toshihiko Ikeuchi.2006～20th International Congress of Biochemistry and Molecular BiologyKyoto, JapanEnglish
International academic conferenceNicotine protects tunicamycin-induced ER stress-mediated apoptosis in PC12 cells.Co-authorHitoshi Nakayama;Takahiro Utsumi;Koji Shimoke;Harue Sasaya;Yuichi Shimamura;Toshihiko Ikeuchi.2006～20th International Congress of Biochemistry and Molecular BiologyKyoto, JapanEnglish
International academic conferenceNerve growth factor prevents ER stress-induced apoptosis in PC12 cells.Co-authorSoichiro Kishi;Koji Shimoke;Harue Sasaya;Kazuo Shin-ya;Toshihiko Ikeuchi.2006～20th International Congress of Biochemistry and Molecular BiologyKyoto, JapanEnglish
International academic conferenceNerve growth factor prevents ER stress-induced apoptosis via down-regulation of Bim expression in PC12 cells.Co-authorKoji Shimoke;Soichiro Kishi;Masashi Hamada;Harue Sasaya;Yuichi Shimamura;Toshihiko Ikeuchi.2006～36th Annual Meeting of Society for NeuroscienceAtlanta, U.S.A.English
Academic presentationModification of histone H3 during neurite outgrowth by cAMP in PC12 cellsUnrefereedCo-authorHiroki Maruoka;Yuichi Shimamura;Harue Sasaya;Soichiro Kishi;Koji Shimoke;Toshihiko Ikeuchi2006～The Japanese Society for NeurochemistryNagoyaEnglishMEXT 20020401-20060331
Research reportIn-house publicationCo-author2005～
PapersERK1/2 are involved in low potassium-induced apoptotic signaling downstream of ASK1-p38 MAPK pathway in cultured cerebellar granule neuronsIn refereedAcademic JournalCo-authorYamagishi S;Matsumoto T;Numakawa T;Yokomaku D;Adachi N;Hatanaka H;Yamada M;Shimoke K;Ikeuchi T.Brain Research1038(2):223-2302005～English
PapersNGF-induced phosphatidylinositol 3-kinase signaling pathway prevents thapsigargin-triggered ER stress-mediated apoptosis in PC12 cellsIn refereedAcademic JournalCo-authorShimoke K;Kishi S;Utsumi T;Shimamura Y;Sasaya H;Oikawa T;Uesato S;Ikeuchi TNeuroscience Letters389, 124-1282005～English
PapersPurification, characterization, and overexpression of psychrophilic and thermolabile malate dehydrogenase of a novel antarctic psychrotorelant, Flavobacterium frigidimaris KUC-1In refereedAcademic JournalCo-authorOikawa T;Yamamoto N;Shimoke K;Uesato S;Ikeuchi T;Fujioka TBioscience, Biotechnology, and Biochemistry69, 2146-21542005～English
Academic presentationNGF prevents 2-deoxy-D-glucose-induced apoptosis via PI3-K signaling pathway in PC12 cells.UnrefereedCo-authorKoji Shimoke;Yuko Yamamoto;Soichiro Kishi;Harue Sasaya;Takahiro Utsumi;Yuichi Shimamura;Kazuo Shin-ya;Toshihiko Ikeuchi.2005～English
Academic presentationRelationship of polyglutamine-expanded GFP expression to ER stress in PC12 cellUnrefereedCo-authorNakayama H;Shimoke K;Yoshitaka N;Isosaki M;Satoh H;Yoshizumi M;Ikeuchi T.2005～English
Academic presentationProtective effect of NGF on 2-deoxy-D-glucose-induced apoptosis via PI3-K signaling pathway in PC12 cellsCo-authorYuko Yamamoto;Koji Shimoke;Soichiro Kishi;Takahiro Utsumi;Kazuo Shin-ya;Toshihiko Ikeuchi.2005～English
Academic presentationNeurite outgrowth is induced by inhibitors of histone deacetylase in PC12 cellsCo-authorYuichi Shimamura;Kiyouhisa Onishi;Hiroki Maruoka;Harue Sasaya;Taishi Maeda;Shinichi Uesato;Koji Shimoke;Toshihiko Ikeuchi.2005～English
International academic conferenceNGF prevents 2-deoxy-D-glucose-induced apoptosis in PC12 cells.Co-authorShimoke K.;Yamamoto Y.;Kishi S.;Sasaya H.;Utsumi T.;Shimamura Y.;Shin-ya K.;Ikeuchi T.2005～35th Annual Meeting of Society for NeuroscienceWashington D.C., U.S.A.English
Academic presentationCo-author2005～
PapersNerve growth factor attenuates endoplasmic reticulum stress-mediated apoptosis via suppression of caspase-12 activity.In refereedAcademic JournalCo-authorShimoke K.;Amano H.;Kishi S.;Uchida H.;Kudo M.;Ikeuchi T.Journal of Biochemistry135(3),439-4462004～EnglishGrant-in-Aid for Scientific Research
Academic presentationCo-author2004～
PapersProtective effect of nicotine on tunicamycin-induced apoptosis of PC12h cellsIn refereedAcademic JournalCo-authorSHIMOKE KojiNeuroscience Letters370(2-3),244-2472004～English
PapersPrevention of endoplasmic reticulum stress-induced cell death by brain-derived neurotrophic factor in cultured cerebral cortical neuronsIn refereedAcademic JournalCo-authorShimoke K.;Utsumi T.;Kishi S.;Nishimura M.;Sasaya H.;Kudo M.;Ikeuchi T.Brain Research1028(1), 105-1112004～English
Academic presentationBDNF prevents ER stress-induced cell death in cultured cerebral cortical neurons2004～English
Academic presentationIdentification and characterization of signaling proteins which bind to the intracellular region of TrkA receptor using yeast two-hybrid systemSHIMOKE,Koji;;;SHIMOKE Koj;IKEUCHI Toshihiko2004～English
International academic conferencePrevention of ER stress-induced cell death by BDNF in cultured cerebral cortical neuronsCo-authorShimoke K.;Utsumi T.;Kishi S.;Sasaya H.;Ikeuchi T.2004～34th Annual Meeting of Society for NeuroscienceSan Diego, U.S.A.English
Academic presentationCo-author2004～
PapersMPTP-induced reactive oxygen species promote cell death through a gradual activation of caspase-3 without expression of GRP78-Bip as a preventive measure against ER stress in PC12 cells.In refereedAcademic JournalCo-authorSHIMOKE Koji;KUDO Motoshige;IKEUCHI ToshihikoLife Sciences73, 581-5932003～EnglishKansai University Special Research Fund 200204-
PapersApoptosis-signal regulating kinase-1 is involved in low potassium-induced activation of p38 mitogen-activated protein kinase and c-Jun in cultured cerebellar granule neuronsIn refereedAcademic JournalCo-authorSHIMOKE KojiJournal of Biochemistry133, 719-7242003～English
PapersComparison of inhibitory effects of brain-derived neurotrophic factor and insulin-like growth factor on low potassium-induced apoptosis and activation of p38 MAPK and c-Jun in cultured cerebellar granule neuronsIn refereedAcademic JournalCo-authorSHIMOKE KojiMolecular Brain Research119, 184-1912003～English
Academic presentationNGF-mediated suppression of caspase-12 activation and apoptosis induced by ER stress in PC12 cellsSHIMOKE Koji2003～
Academic presentationProtective effect of nicotine on tunicamycin-induced apoptosis of PC12 cellsSHIMOKE Koji2003～
Academic presentationSHIMOKE,Koji2003～
Academic presentationCo-authorSHIMOKE,Koji2003～
PapersIn-house publicationCo-author2003～
International academic conferenceNGF-mediated suppression of caspase-12 activation and apoptosis induced by ER stress in PC12 cellsCo-authorShimoke K;Amano H;Nishimura M;Utsumi T;Kuromi Y;Ikeuchi T2003～33rd Annual Meeting of Society for NeuroscienceNew Olreans, U.S.A.
Papers1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine has a transient proliferative effect on PC12h cells and nerve growth factor additively promotes this effect:possible involvement of destinct mechanisms of activation of MAP kinase family proteins.In refereedAcademic JournalCo-authorSHIMOKE KojiDevelopmental Brain Research2002～English
Academic presentationCo-authorSHIMOKE,Koji2002～
Academic presentationCo-authorSHIMOKE,Koji2002～
Academic presentationCo-authorSHIMOKE,Koji2002～
PapersSuppression of angiogenesis causes a significant delay of repair process in rat thromboembolic cerebral infarction.In refereedIn-house publicationCo-authorSHIMOKE KojiJournal of Tokyo Medical University2002～English
PapersNerve growth factor prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced cell death via the Akt pathway by suppressing caspase-3-like activity using PC12 cells:Relevance to therapeutical application for Parkinson's desease.In refereedAcademic JournalCo-authorSHIMOKE KojiJounal of Neuroscience Research2001～English
PapersDifferences in survival-promoting effects and intracellular singnaling properties of BDNF and IGF-1 in cultured cerebral cortical neurons.In refereedAcademic JournalCo-authorSHIMOKE KojiJournal of Neurochemistry2001～
BookUnrefereedOtherCo-authorSHIMOKE,Koji1999～
PapersInhibition of phosphatidylinositol 3-kinase activity elevates c-Jun N-teminal kinase activity in apoptosis of cultures cerebellar granule neurons.In refereedAcademic JournalCo-authorSHIMOKE KojiDevelopmental Brain Research1999～English
PapersBDNF exerts a preventive effect on lowK± induced apoptosis of cerebellar granule neurons via actibation of PI3-kinase.UnrefereedIn-house publicationCo-authorSHIMOKE KojiKeio University symposia for life science and medicine,Neural Development1999～English
Academic presentationCo-authorSHIMOKE,Koji1999～
Academic presentationCo-authorSHIMOKE,Koji1999～
Academic presentationCo-authorSHIMOKE,Koji1998～
Academic presentationCo-authorSHIMOKE,Koji1998～
Academic presentationInhibition of phosphatidylinositol 3-kinase activity elevates c-Jun N-terminal kinase actibity in apoptosis of cultured cerebellar granule neurons.Single-AuthorSHIMOKE Koji1998～Society for Neurocsience 28th Annual MeetingSan Diego, U.S.A.English
BookUnrefereedOtherCo-authorSHIMOKE,Koji1998～
PapersApoptosis-inducing and-preventing signal transduction pathways in cerebellar granule neurons.In refereedAcademic JournalCo-authorSHIMOKE KojiHuman Cell1998～English
PapersSynthetic lipid products of PI3-kinase which are added to culture medium prevent lowK(+)-induced apoptosis of cerebellar granule neurons via Akt kinase activation.In refereedAcademic JournalCo-authorSHIMOKE KojiFEBS Letters1998～English
BookAcademic JournalSingle-AuthorSHIMOKE,Koji1997/7～
PapersInvolvement of phosphatidylinositol-3 kinase in prevention of low K(+)-induced apoptosis of cerebellar granule neurons.In refereedAcademic JournalCo-authorSHIMOKE KojiDevelopmental Brain Research1997～English
Academic presentationSpecific inhibitors of PI-3 kinase,wortmaninn and LY294002,inhibit survival effects of potassium depolarization and brain-derived neurotrophic factor in cerebellar granule neurons.Co-authorSHIMOKE Koji1997～Society for Neuroscience 27th Annual MeetingNew Orleans, U.S.A.English
Academic presentationCo-authorSHIMOKE,Koji1997～
PapersSignaling pathways and survival effects of BDNF and NT-3 on cultures cerebellar granule cells.In refereedAcademic JournalCo-authorSHIMOKE KojiDevelopmental Brain Research1996～English
Academic presentationSHIMOKE,Koji1996～
Academic presentationDistinct biochemical properties and survival effects of BDNF and NT-3 on cultured cerebellar granule cells.Co-authorSHIMOKE Koji1995～Society for Neuroscience 25th Annual MeetingSan Diego, U.S.A.English
Academic presentationCo-authorSHIMOKE,Koji1994～
PapersActivation of aromatic carbon-hydrogen bonds of methylsubstituted benzenes by the palladium(Ⅱ) acetate-diisobutyl sulphide systemIn refereedAcademic JournalCo-authorSHIMOKE KojiPolyhedron1991～English
PresentationsActivation of Aromatic Carbon-Hydrogen Bonds by Palladium(II) Acetate- Diisobutyl Sulfide and -Dipropyl Selenide SystemsSHIMOKE Koji1991～38th Symposium on Organometallic Chemistry, Japan
Community Activities
- Clinical Pharmacology and Biopharmaceutics, Executive Editor 2011/10
Participation in International Conferences
- The society for neuroscience 1997
- The society for neuroscience 2003
- The society for neuroscience 2004
- The society for neuroscience 2005
- The society for neuroscience 2006
- International Congress of Biochemistry and Molecular Biology 2006
- The society for neuroscience 2007
- 38th Annual Meeting of Society for Neuroscience 2008
- 17th Euro-conference on apoptosis 2009
- 39th Annual Meeting of Society for Neuroscience 2009
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