NAGAOKA, Yasuo |
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Faculty, Department/Institute
- Faculty of Chemistry, Materials and Bioengineering Department of Life Science and Biotechnology
Academic status (qualification)
- Professor Apr. 1,2010
Position
- Dean, Faculty of Chemistry, Materials and Bioengineering 2022/10/1~2024/9/30
- Dean, Graduate School of Engineering 2022/10/1~2024/9/30
Undergraduate Degrees・University
- Meiji Pharmaceutical University Faculty of Pharmaceutical Science1989 Graduated
Graduate Degrees・University
- Kyoto University Master's Degree Program 1992 Completed
- Kyoto University Doctor's Degree Program Withdrawal
Academic Degrees
- Mar. 1991 Kyoto University
- Ph.D Sep. 1996 Kyoto University
Homepage Address, E-mail Address
- Homepage Address:http://pharm.life-bio.kansai-u.ac.jp/
Research fields
Research fields | keyword |
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Molecular pharmaceutics | Synthetic medicinal chemistry;medicinal chemistry; |
Research topics
research topic | Structure and function of channel forming peptides, in lipid bilayers and biomembrans. |
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Study theme state | Joint Research within Institution |
research duration | |
Research Programs | |
keyword | ion channel lipid bilayer,trichosporin, |
Research field | |
Research Topics Overview |
research topic | Asymmetric synthesis utilizing external chiral ligands |
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Study theme state | Joint Research within Institution |
research duration | |
Research Programs | |
keyword | asymmetric synthesis,chiral ligand, |
Research field | |
Research Topics Overview |
research topic | Development of Drugs |
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Study theme state | Joint research within Japan |
research duration | |
Research Programs | |
keyword | anticancer drugs, |
Research field | |
Research Topics Overview |
Research Activities
- 1992-2001 Research Assiciate, Kyoto University, Graduate school of Pharmaceutical Sciences. 2001-present Associate Professor, Kansai University, Faculty of Chemistry, Materials and Bioengineering
Awards
- Jan. 19,2001
Academic Associations
所属学会・団体名 | 役職名 (役職在任期間) |
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The Pharmaceutical Society of Japan | |
The Society for Biotechnology, Japan | |
American Chemical Society |
Intellectual Property Rights
- (Pending)
- N-hydroxy carboxamide derivatives application number:2002-045310 (Feb. 2002)
Research Publications
PapersAsymmetric Synthesis of t-Butyl 3-Alkyl-oxindole-3-carboxylates via Chiral Phosphoric Acid-Catalyzed Desymmetrization of Di-t-butyl 2-Alkyl-2-(2-aminophenyl)malonatesIn refereedAcademic JournalCo-authoredKyoji Ishida;Masahiro Shimizu;Yusuke Yamai;Itaru Natsutani;Shinichi Uesato;Yasuo Nagaoka;Takaaki SumiyoshiHeterocycles99(2), 1398 -14112019/2~10.3987/COM-18-S(F)87
PapersMonitoring of glutamate-induced excitotoxicity by mitochondrial oxygen consumptionIn refereedAcademic JournalCo-authoredAyako Kumagai;Tsutomu Sasaki;Hidehisa Kawahara;Yasuo Nagaoka;Kenji Kawabata;Miho Kusuda;Hiroshi TakemoriSynapse73(1)2019/1~10.1002/syn.22067Ayako Kumagai, Tsutomu Sasaki, Hidehisa Kawahara, Yasuo Nagaoka, Kenji Kawabata, Miho Kusuda Furue, Hiroshi Takemori,
PapersIn refereedAcademic JournalCo-authored;;;;;;;2017/12~10.3987/COM-17-S(T)2
PapersIn refereedAcademic JournalCo-authoredNAGAOKA,Yasuo;;;;;;2017/12~10.3987/COM-18-S(T)82
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International academic conferenceCo-authored;;;;2017/8~
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PapersIn refereedAcademic JournalCo-authoredA. Kuroi;K. Sugimura;A. Kumagai;A. Kohara;Y. Nagaoka;H. Kawahara;M. Yamahara;N. Kawahara;H. Takemori;H. Fuchino2017/7~
International academic conferenceCo-authored;;2016/7~
PapersSynergistic Antitumor Effect of a Combination of Paclitaxel and Carboplatin with Nobiletin from Citrus depressa on Non-Small-Cell Lung Cancer Cell LinesIn refereedAcademic JournalCo-author;;;;;;;;;;;Planta Med.80(6), 452-72014/4~10.1055/s-0034-1368321
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PapersInduction of melanogenesis by 40-O-methylated flavonoids in B16F10 melanoma cellsIn refereedAcademic JournalCo-authorIppei Horibe;Yudai Satoh;Yuki Shiota;Ayako Kumagai;Nanao Horike;Hiroshi Takemori;Shinichi Uesato;Shuji Sugie;Katsuyoshi Obata;Hidehisa Kawahara;Yasuo Nagaoka;J. Nat. Med.67(4), 705-7102013/10~10.1007/s11418-012-0727-y
International academic conferenceIn refereedOtherCo-author;;;;;;;2013/7/3~2013/7/549th International Conference on Medicinal Chemistry (RICT 2013)
International academic conferenceIn refereedOtherCo-author;;;;;;2013/7/3~2013/7/5
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PapersIn refereedAcademic JournalCo-authorNAGAOKA,Yasuo;;;;;;;;;;;2012/12/4~10.1007/s11418-012-0727-y
International academic conferenceNAGAOKA,Yasuo;;;;2012/8/30~
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International academic conferenceIn refereedCo-authorNAGAOKA,Yasuo;;;;;2012/8/30~Universiti Sains Malaysia, Penang, Malaysia
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International academic conferenceNAGAOKA,Yasuo;;;;;;;2012/7/4~2012/7/6
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PapersIn refereedAcademic JournalCo-authorNAGAOKA,Yasuo;;;;;;;;;2012/5/25~10.1371/journal.pone.0037803
PapersIn refereedAcademic JournalCo-authorNAGAOKA,Yasuo;;;2012/4~
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Academic presentationNAGAOKA,Yasuo;;2012/1/24~
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International academic conferenceIn refereedOtherNAGAOKA,Yasuo;;;;;;2011/11/29~2011/12/2
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International academic conferenceIn refereedOtherNAGAOKA,Yasuo;;;;;;;2011/10/17~2011/10/20
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Academic presentationNAGAOKA,Yasuo;2011/1/14~
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PapersDownregulation of SIK2 expression promotes the melanogenic program in miceIn refereedAcademic JournalCo-authorNanao Horike;Ayako Kumagai;Yuko Shimono;Tomoko Onishi;Yumi Itoh;Tsutomu Sasaki;Kazuo Kitagawa;Osamu Hatano;Hiroaki Takagi;Teruo Susumu;Hiroshi Teraoka;Ken-ichi ;Yasuo Nagaoka;Hidehisa Kawahara;Hiroshi Takemori;Pigment Cell Melanoma Res.23; 809–819 (2010)2010/10~
PapersTherapeutic Effect of Arctiin and Arctigenin in Immunocompetent and Immunocompromised Mice Infected with Influenza A VirusIn refereedAcademic JournalCo-authorKyoko Hayashi;Kazuto Narutaki;Yasuo Nagaoka;Toshimitsu Hayashi;Shinichi Uesato;Biol. Pharm. Bull.33(7) 1199-1205 (2010)2010/7~
PapersMolecular bases of cyclodextrin adapter interactions with engineered protein nanoporesIn refereedAcademic JournalCo-authorArijit Banerjee;Ellina Mikhailova;Stephen Cheley;Li-Qun Gu;Michelle Montoyac;Yasuo Nagaoka;Eric Gouaux;Hagan Bayley;Proc Natl Acad Sci U S A107(18) 8165-70 (2010)2010/5~
PapersHistone Deacetylase Inhibitor Prodrugs in Nanoparticle Vector Enhanced Gene Expression in Human Cancer CellsIn refereedAcademic JournalCo-authorY. Ishii;Y. Hattori;T. Yamada;S. Uesato;Y. Maitani;Y. Nagaoka;Euro. J. Med. Chem44 (11) 4603-4610 (2009)2009/11~
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PapersInhibitory Effect of (-)-Epigallocatechin and (-)-Epigallocatechin Gallate against Heregulin β1-Induced Migration/Invasion of the MCF-7 Breast Carcinoma Cell LineCo-authorYukihiro Kushima ;Kazuki Iida;Yasuo Nagaoka;Yasuyuki Kawaratani;Tatsuya Shirahama;;Minoru Sakaguchi;Kimiye Baba;Yukihiko Hara;Shinichi Uesato;;Biol. Pharm. Bull.32 (5), 899-904 2009~
PapersExamination of Anti-proliferative Activities of (-)-Epogallocatechin against HCT116 Colorectal Carcinoma CellsIn refereedAcademic JournalCo-authorHiroyuki Inaba;Yasuo Nagaoka;Yukihiro Kushima;Ayako Kumagai;Yoshinori Matsumoto;Minoru Sakaguchi;Kimiye Baba;Shinichi Uesato;;Biol. Pharm. Bull. 31(1), 79-84 (2008)31(1), 79-842008~Grant-in-Aid for Scientific Research
Academic presentationCo-authorNAGAOKA,Yasuo;;;;Chan Lai Keng;Tan Chee Leng;;2008~
Building an International Network Exchange
Program of Education and Research for Graduate Course Students in Life and Biotechnology
Co-authorT. Oikawa;S. Uesato;H. Tamura;H. Kawahara;Y. Nagaoka;K. Shimoke;T. Tsuchido;L. Eggeling;Volker F. Wendisch;Jochen Buchs;Ratana Rujiravanit;Nazalan Najimudin;Chan Lai Keng;;Science and technology Report of Kansai University50, 83-942008~
PapersGrowth Inhibition of Human Colon Cancer Cell Line HCT116 by Bis [2-(acylamino)phenyl] Disulfide and Its Action MechanismCo-authorS. Yamakawa;A. Demizu;Y. Kawaratani;Y. Nagaoka;Y. Terada;S. Maruyama;S. Uesato;;Biol. Pharm. Bull31 (5), 916-9202008~
Papers
Effects of Phosphorylation of Immunomodulatory agent FTY720 (Fingolimod) on antiproliferative activity against
breast and colon cancer cells
Co-authorY. Nagaoka;K. Otsuki;T. Fujita;S. Uesato;;Biol. Pharm. Bull31 (6), 1177-11812008~
PapersAttempt to Detect Natural Anticancer Compounds-Protein Binding through Precursor Ion Scan and MS/MS MeasurementsCo-authorJ. Negishi;T. Shirahama;Y. Nagaoka;Y. Takemoto;S. Uesato;;J. Pharm. Soc. Japan128(9), 1317-13232008~
PapersPeptide Backbone Mutagenesis of Putative Gating Hinges in a Potassium Ion ChannelCo-authorY. Nagaoka;L. Shang;A. Banerjee;H. Bayley;S. J. Tucker;;ChemBioChem9, 1725-17282008~
Academic presentationCo-authorNAGAOKA,Yasuo;;;;;;;;;;2008~
Academic presentationCo-authorNAGAOKA,Yasuo;;;;;;;;;2008~
PapersInvestigation of the antibacterial activity of 3-O-octanoyl-(-)-epicatechinCo-authorT.P.T. Cushnie;P.W. Taylor;Y. Nagaoka;S. Uesato;Y. Hara;A.J. Lamb;;J. Appl. Micorob.105 (2008) 1461-14692008~
Hair-growth stimulating activity of biflavones from Ginkgo bilobaCo-authorYasuo Nagaoka;Norihisa Yasuda;Itsuki Kuwajima;Shinich Uesato;;ICPH2007 3rd International Conference on Polyphenols and HealthAbstract pp. 253 (P200)2007/11/25~2007/11/28Kyoto International Conference Center, Kyoto Japan
Comparative examination of anti-proliferative activities of (-)-epigallocatechin gallate and (-)-epicatechin against HCT 116 colon
cancer cell
Co-authorShinichi Uesato;Hiroyuki Inaba;Yasuo Nagaoka;Minoru Sakaguchi;Kimie Baba;Yukihiko Hara;;ICPH2007 3rd International Conference on Polyphenols and HealthAbstract pp. 275 (P237)2007/11/25~2007/11/28Kyoto International Conference Center, Kyoto Japan
(-)-Eepigallocatechin-3-gallate and (-)-epigallocatechin inhibit herigulin b1-induced migration/invasion of MCF-7 breast carcinoma cell lineCo-authorYukihiro Kushima;Kazuki Iida;Yasuo Nagaoka;Yukihiko Hara;Shinichi Uesato;;ICPH2007 3rd International Conference on Polyphenols and HealthAbstract pp. 303 (P289)2007/11/25~2007/11/28Kyoto International Conference Center, Kyoto Japan
Academic presentationCo-authorNAGAOKA,Yasuo;;;;;;;;2007/3/28~2007/3/30
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PapersIon channels of N-terminally linked alamethicin dimers: Enhancement of cation-selectivity by substitution of Glu for Gln at position 7In refereedAcademic JournalCo-authorTakashi Okazaki;Yasuo Nagaoka;Koji Asami;;Bioelectrochemistry 70, 380–386 (2007)70, 380–3862007~
Academic presentationAntiviral activity of berberine and related compounds against human cytomegalovirusCo-authorKyoko Hayashi;Kazuki Minoda;Yasuo Nagaoka;Toshimitsu Hayashi;Shinichi Uesato;;Bioorg. & Med. Chem. Lett.17, 1562-15642007~
Proceeding of the International Symposium in Science and Technology 2007Co-authorShinichi Uesato;Yasuo Nagaoka;Kyoko Hayashi;;Collaboration between ASEAN Countries in Environment and Life SciencesBT-62007~Kansai University
Proceeding of the International Symposium in Science and Technology 2007Co-authorYukihiro Kushima;Kazuki Iida;Yasuo Nagaoka;Shinichi Uesato;;Collaboration between ASEAN Countries in Environment and Life SciencesPO-192007~Kansai University
Explorative Study of Hair Growth Stimulants in Plants from Malaysia-Collaboration Work with Prof. Chan-, Proceeding of the International Symposium in Science and Technology 2007Single-AuthorYasuo Nagaoka;;Collaboration between ASEAN Countries in Environment and Life SciencesBT-72007~Kansai University
Academic presentationCo-authorNAGAOKA,Yasuo;;;Chan Lai Keng;Tan Chee Leng;;2007~
Academic presentationSingle-AuthorNAGAOKA,Yasuo;;2007~
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Academic presentationCo-authorNAGAOKA,Yasuo;;;;;;2006/6/15~2006/6/16
PapersCytoprotective effect of novel histone deacetylase inhibitors against polyglutamine toxicityIn refereedAcademic JournalCo-authorShingo Kariya;Makito Hirano;Shinichi Uesato;Yoshitaka Nagai;Yasuo Nagaoka;Yoshiko Furiya;Hirohide Asai;Nobuhiro Fujikake;Tatsushi Toda;Satoshi Ueno;;Neuroscience Letters 392(3), 213–215 (2006)392(3), 213–2152006~
PapersStereoselective conversion of anhydrovinblastine into vinblastine utilizing an anti-vinblastine monoclonal antibody as a chiral mouldIn refereedAcademic JournalCo-authorTatsuya Shirahama;Takeyuki Kohno;Tomohiro Kaijima;Yasuo Nagaoka;Daisuke Morimoto;Kazumasa Hirata;Shinichi Uesato;;Chem. Pharm. Bull., 54(5), 665-668 (2006)54(5), 665-6682006~Grant-in-Aid for Scientific Research
PapersSynthesis and cancer antiproliferative activity of new histone deacetylase inhibitors: hydrophilic hydroxamates and 2-aminobenzamide-containing derivativesIn refereedAcademic JournalCo-authorY. Nagaoka;T. Maeda;Y. Kawai;D. Nakashima;T. Oikawa;K. Shimoke;T. Ikeuchi;H. Kuwajima;S. Uesato;;European Journal of Medicinal Chemistry 41(6), 697–708 (2006)41(6), 697–7082006~Grant-in-Aid for Scientific Research
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Co-authorNAGAOKA,Yasuo;;;;2006~
Cicadapeptins from a Fungus Isaria sinclairii Inhibit Acetylcholine- Evoked Secretion of Catecholamines from Bovine Adrenal Chromaffin CellsCo-authorYasuo Nagaoka;Kousuke Hata;Naofumi Fukata;Shinichi Uesato;Junya Ueda;Keiichiro Higashi;Shuji Uchida;Tetsuro Fujita;Shigeo Sasaki;Eiichi Tachikawa;Hitoshi Ishida(ed);Hisakazu Mihara(ed);;Peptide Science 2006, Japanese Peptide Society. 2482006~
Proceeding of the international conference of 43rd Japanese peptide symposium and 4th peptide engineering meetingCo-authorYasuo Nagaoka;Kousuke Hata;Naofumi Fukata;Shinichi Uesato;Junya Ueda;Keiichiro Higashi;Shuji Uchida;Tetsuro Fujita;Shigeo Sasaki;Eiichi Tachikawa;;43JPS/PEM45-82006~
Academic presentationCo-authorNAGAOKA,Yasuo;;;;;;2006~
Academic presentationCo-authorNAGAOKA,Yasuo;;;;2006~
Academic presentationIon channels of N-terminally linked alamethicin dimers:Enhancement of cation-selectivity by substitution of Glu for Gln at position 7Co-authorTakashi Okazaki;Yasuo Nagaoka;Koji Asami;;Bioelectrochemistry71, 68-742006~
New Histone Deacetylase Inhibitors: Benzamide derivatives with a 2-hydroxyethylamino groupCo-authorYasuo Nagaoka;Taishi Maeda;Shinichi Uesato;;230th ACS National Meeting, Abstracts of Papers,MEDI 3622005/8/28~2005/9/1Washington, DC
PapersInhibitory effect of cancer cell proliferation by novel histone deacetylase inhibitors involves p21/WAFI induction and G2/M arrestCo-authorT. Maeda;Y. Nagaoka;Y. Kawai;N. Takagaki;C. Yasuda;S. Yogosawa;Y. Sowa;T. Sakai;S. Uesato;;Biological and Pharmacentical Bullten2005/5~
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PapersEffect of 3-0-Octanoyl-(+)-catechin on the Responses of GABA A Receptors and Na+/Glucose Co transporters Expressed in Xenopus OocytesCo-authorH. Aoshima;Y. Okita;S. Hossain;K. Fukue;M. Mito;Y. Orihara;T. Yokoyama;A. Kumagai;Y. Nagaoka;S. Uesato;;Journal of Agricultural Food Chemistry2005/2~
PapersTumor Chemopreventive Effect of Orally Administered (-)-Epigallocatechin and its 3-0-Acylated Derivatives on the Two stage Mouse Skin CarcinogenesisCo-authorY. Nagaoka;A. Kumagai;Y. Tokuda;H. Nishino;S. Uesato;;Natural Medicines2005/1~
PapersTumor chemopreventive effect of orally administered (-)-epigallocatechin and its 3-O-acylated derivatives on the two stage mouse skin carcinogenesis induced by peroxynitrite and 12-O-tetradecanoylphorbol-13-acetate.In refereedAcademic JournalCo-authorYasuo Nagaoka;Ayako Kumagai;Harukuni Tokuda;Hoyoku Nishino;Yukihiko Hara;Shinichi Uesato;;Natural Medicine, 59(1), 49-51 (2005)59(1), 49-512005~Grant-in-Aid for Scientific Research
PapersInhibitory effect of cancer cell proliferation by novel histone deacetylase inhibitors involves p21/WAF1 induction and G2/M arrest.In refereedAcademic JournalCo-authorTaishi Maeda;Yasuo Nagaoka;Yuki Kawai;Nobumasa Takagaki;Chikako Yasuda;Shingo Yogosawa;Yoshihiro Sowa;Toshiyuki Sakai;Shinichi Uesato.;;Biol. Pharm. Bull., 28(5), 849-853 (2005).28(5), 849-8532005~Grant-in-Aid for Scientific Research
PapersEffect of 3-O-Octanoyl-(+)-catechin on the Responses of GABAA Receptors and Na+/Glucose Cotransporters Expressed in Xenopus Oocytes and on the Oocyte Membrane Potential.In refereedAcademic JournalCo-authorHitoshi Aoshima;Yoichi Okita;Sheikh Julfikar Hossain;Keiko Fukue;Mariko Mito;Yusuke Orihara;Terufumi Yokoyama;Mamoru Yamada;Ayako Kumagai;Yasuo Nagaoka;Shinichi Uesato;Yukihiko Hara;;J. Agric. Food Chem., 53, 1955-1959 (2005)53, 1955-19592005~Grant-in-Aid for Scientific Research
PapersIn refereedAcademic JournalCo-authorNAGAOKA,Yasuo;NAGAOKA Yasuo;;;2005~
PapersPotent Histone Deacetylase Inhibitors: N-hydroxybenzamides with Antitumor ActivitiesCo-authorT. Maeda;Y. Nagaoka;H. Kuwajima;C. Seno;S. Maruyama;M. Kurotani;S. Uesato;;Bioorganic and Medicinal Chemistry12, 4351-43602004/8~
PapersAnti-Staphylococus aureus activity and oxacillin resistance modulating capacity of 3-0-acyl-catechinsCo-authorP. D. Stapleton;S. Shah;J. Miller;Y. Hara;Y. Nagaoka;A. Kumagai;S. Uesato;P. Taylor;;International Journal of Antimicrobial Agents2004/2~
Academic presentationCo-authorNAGAOKA,Yasuo;;;;;;;2004~
BookModern Allene ChemistryCo-authorH. Ohno;Y. Nagaoka;K. Tomioka;Norbert Krause(ed.);;Wileypp. 141-1812004~
Academic presentationCo-authorNAGAOKA,Yasuo;;;;;;Peter W. Taylor, Paul D. Stapleton;;;2004~
PapersInhibitory Effects of 3-O-acyl-(+)-catechins on Epstein-Barr Virus Activation.In refereedAcademic JournalCo-authorS. Uesato;K. Taniuchi;A. Kumagai;Y. Nagaoka;R. Seto;Y. Hara;H. Tokuda;H. Nishino;Epstein-Barr Virus;catechin;Chem. Pharm. Bull.51/12, 1448-14502003/12~Grant-in-Aid for Scientific Research
PapersIon channels of alamethicin dimer N-terminally linked by disulfide bond.In refereedAcademic JournalCo-authorT. Okazaki;M. Sakoh;Y. Nagaoka;K. Asami;ion channel;peptaibol;dimer;alamethicin;Biophys. J.85, 267-2732003/7~Grant-in-Aid for Scientific Research
PapersN-terminal insertion of alamethicin in channel formation studied using its covalent dimer N-terminally linked by disulfide bondIn refereedAcademic JournalCo-authorM. Sakoh;T. Okazaki;Y. Nagaoka;K. Asami;disulfide;ion chamel;alamethicin;Biochim. Biophys. Acta1612, 117-1212003/7~Grant-in-Aid for Scientific Research
PapersAsymmetric Michael-aldol tandem cyclization of -oxo-,-unsaturated esters with 10-mercaptoisoborneol methyl etherIn refereedAcademic JournalCo-authorK. Nishimura;H. Tsubouchi;M. Ono;T. Hayama;Y. Nagaoka;K. Tomioka;Michael-aldol;Asymmetric cyclization;Tetrahedron Lett.44, 2323-23262003/2~Grant-in-Aid for Scientific Research
PapersAntiproliferative Activity of Some Catechins against Her2/neu-Overexpressing Human Breast Carcinoma SKBR3In refereedAcademic JournalCo-authorNAGAOKA Yasuo;T. Maeda;Y. Nagaoka;S. Kobayashi;Y. Hara;H. Tokuda;H. Nishimo;S. Uesato;epigallocatechin gallate;epigallocatechin;Catechin;Breast Cancer;Her2/neu;Natural Medicines57/1, 31-332003/1~Grant-in-Aid for Scientific Research
PapersIn refereedAcademic JournalSingle-AuthorNAGAOKA,Yasuo;trichosporin;ion channel;peptaibol;2003~
PapersTumor Chemopreventive Activity of 3-O-Acylated(-)-epigallocatechinsIn refereedAcademic JournalCo-authorA. Kumagai;Y. Nagaoka;T. Obayashi;Y. Terashima;H. Tokuda;Y. Hara;T. Mukainaka;H. Nishino;H. Kuwajima;S. Uesato;cafechin derivafive;cancer;promoter;tumor;catechin;Bioorg. Med. Chem.11,5143-51482003~
PapersSynthesis and Application of Chiral Bisphosphines through Lithiation-Conjugate Addition Tandem Cyclization of Chiral ,,,-Unsaturated Bisphosphine OxideIn refereedAcademic JournalCo-authorYasuo Ngaoka;Hideki Inoue;Nawal El-Kossi;Kiyoshi Tomioka;conjugate addition;chiral bisphosphine;tandem cyclization;bisphosphine;chem.commun2002/2,122-1232002~Grant-in-Aid for Scientific Research 200004-200303
PapersSynthesis of Allenes by Double Horner-Wadsworth-Emmons ReactionIn refereedAcademic JournalCo-authorHideki Inoue;Hiroshi Tsubouchi;Yasuo Nagaoka;Kiyoshi Tomioka;Phosphonate;Wittich reaction;Horner-Emmons reaction;allene;Tetrahedron58/1,83-902002~Grant-in-Aid for Scientific Research 200004-200303
PapersAllenes Through Horner-Wadswoth-Emmons Olefination of AlkenylphosphonatesIn refereedAcademic JournalCo-authorYasuo Nagaoka;Hideki Inoue;Kiyoshi Tomioka;Phosphonate;Horner-Emmons reaction;allene;Phosphorous, Sulfurand Silicon177/6,1843-48462002~Grant-in-Aid for Scientific Research 200004-200303
PapersNovel Histone Deacetylase Inhibitors: N-Hydroxycarboxamids Possessing a Terminal Bicyclic Aryl GroupIn refereedAcademic JournalCo-authorShinichi Uesato;Manabu Kitagawa;Yasuo Nagaoka;Taishi Maeda;Hiroshi Kuwajima;Takao Yamori;inhibitor;Histone deacetylase;Bioorg. Med. Chem. Left.12/10,1347-13492002~Grant-in-Aid for Scientific Research 200004-200303
PapersConjugate reduction-initiated tandem cyclization of a chiral ,,,-unsaturated bisphosphine oxideIn refereedAcademic JournalCo-authorYasuo Nagaoka;Nawal El-Koussi;Shinichi Uesato;Kiyoshi Tomioka;tandem cyclization;conjugate reduction;Tetrahedron Lett.43/24,4355-43592002~Grant-in-Aid for Scientific Research 200004-200303
PapersA New Methodology for Synthesis of A Chiral Phosphinocarboxylic Acid Through Micael Cyclization-Aldol Tandem Reaction of Chiral ,,,-Unsaturated Bisphosphine Oxide and Application in Palladium-Catalyzed Asymmetric Allylic AlkylationIn refereedAcademic JournalCo-authorHideki Inoue;Yasuo Nagaoka;kiyoshi Tomioka;confugate cyclization;chiral ligand;J.Org.Chem.67/16,5864-58672002~Grant-in-Aid for Scientific Research 200004-200303
PapersModification of alamethicin ion channels by substitution of Glu-7 for Gln-7In refereedAcademic JournalCo-authorKoji Asami;Takashi Okazaki;Yasuaki Nagai;Yasuo Nagaoka;alamethicin;ion channel;Biophys.J.83,219-2282002~Grant-in-Aid for Scientific Research 200004-200303
PapersSubstituted Hydroxyureas as Urease InhibitorsIn refereedAcademic JournalCo-authorShinichi Uesato;Yuichiro Hashimoto;Masaru Nishino;Yasuo Nagaoka;Hiroshi Kuwajima;hydroxyurea;Urease inhibitor;Urease;Chem. Pharm. Bull.50/9,1280-12822002~Grant-in-Aid for Scientific Research 200004-200303
PapersCatalytic Enantioselective Protonation of Lithium Ester Enolates Generated by Conjugate Addition of Arylthiolate Enoates.In refereedAcademic JournalCo-authorKatsumi Nishimura;Masashi Ono;Yasuo Nagaoka;Kiyoshi Tomioka;chiral synthesis;protonation;external ligand;Angew. Chem. Int. Ed, ,40(2), pp.440-4422001~
PapersElectronic and Steric Control in Regioselective Addition Reaction of Organolithium Reagents with Enaldimines.In refereedAcademic JournalCo-authorKiyoshi Tomioka;Yoshito Shioya;Yasuo Nagaoka;Ken-ichi Yamada;1,4-addition;organolithium;Michael addition;conjugate addition;J.Org.Chem.66/21,7051-70542001~Grant-in-Aid for Scientific Research 200004200303
PapersTotal Synthesis of (-)-Neplanocin A by Using Lithium Thiolate-Initiated Michael-Aldol Tandem Cyclization ReactionIn refereedAcademic JournalCo-authorMasashi Ono;Katsumi Nishimura;Hiroshi Tsubouchi;Yasuo Nagaoka;Kiyoshi Tomioka;Michael-Aldolreaction;tandem cyclization;Neplanocin;J.Org.Chem66/24,8199-82032001~Grant-in-Aid for Scientific Research 200004200303
PapersMolecular Assembly and Gelating Behavior of Didodecanoylamides of ,-Alkylidenediamides.In refereedAcademic JournalCo-authorKiyoshi Tomioka;Takaaki Sumiyoshi;Shinobu Narui;Yasuo Ngaoka;Akira Iida;Yoshihisa Miwa;Tooru Taga;Minoru Nkano;Tetsuro H;a.;diamide;gelator;gel;J.Am.Che.Soc.123/47,11817-118182001~Grant-in-Aid for Scientific Research 200004-200303
PapersIn refereedAcademic JournalSingle-AuthorNAGAOKA,Yasuo;carbon-carbon boud;cyclization;allene;alkenylphosphonate;2001~Grant-in-Aid for Scientific Research 200004-200303
PapersAn activated phosphate for an efficient Amide and peptide coupling reagentIn refereedAcademic JournalCo-authorTomohisa Yasuhara;Yasuo Nagaoka;Kiyoshi Tomioka;shosphate;condensation;coupling reagent;J. Chem. Soc. Perkin Trans. 12000~
PapersThe Conjugate Addition-Aldol Tandem Reaction of , -Unsaturated Esters Catalyzed By Lithium Benzene thiolateIn refereedAcademic JournalCo-authorMasashi Ono;Katsumi Nishimura;Yasuo Ngaoka;Kiyoshi Tomioka;lithium thiolate;thiophenol;Michael addition;Tetrahedron Lett.1999~
PapersEfficient Cyclization of -Oxo-, -Unsaturated Esters Using Lithium Thiolate-Initiated Michael-Aldol Tandem ReactionIn refereedAcademic JournalCo-authorMasashi Ono;Katsumi Nishimura;Yasuo Nagaoka;Kiyoshi Tomioka;lithium thiolate;tandem cyclization;cyclization;Michael-Aldol reaction;Tetrahedron Lett.1999~
PapersChemoselective Alchoxycarbonylation Reagent Having Trifluoromethane-sulfonyl-4-trifluoromethylanilide as a Leaving GroupIn refereedAcademic JournalCo-authorTomohisa Yasuhara;Yasuo Nagaoka;Kiyoshi Tomioka;condensation reagent;chemoselective condensation;J. Chem. Soc. , Perkin Trans. 11999~
PapersCyclization of ,,,-unsaturated bisphosphonates using organolithium-initiated conjugate addition-Michael tandem reactionIn refereedAcademic JournalCo-authorYasuo Nagaoka;Kiyoshi Tomioka;organolithium;tandem cyclization;Org. Lett.1999~
PapersStructural Requirements of a Chiral Ligand for the Catalytic Asymmetric Addition of Thiophenol to , -Unsaturated Esters.In refereedAcademic JournalCo-authorK. Tomioka;M. Okuda;K. Nishimura;S. Manabe;M. Kanai;Y. Nagaoka;K. Koga;thiophenol;asymmetric reaction;chiral ligand;Tetrahedron Lett.1998~
PapersAn External Chiral Amidophosphine Ligand for Asymmetric Conjugate Addition of OrganocopperIn refereedAcademic JournalCo-authorY. Nakagawa;M. Kanai;Y. Nagaoka;K. Tomioka;conjugate addition;chiral amidophosphine;external ligand;Tetrahedron1998~
PapersBaylis-Hillman Type Carbon-Carbon Bond Formation of Alkenylphosphonates by the Action of Lithium DiisopropylamineIn refereedAcademic JournalCo-authorY. Nagaoka;K. Tomioka;allene;alkenyphosphonate;Michael reaction;conjugate addition;Baylis-Hillman reaction;J. Org. Chem.1998~
PapersEnantioselective Conjugate Addition of Diethylzinc to Cyclohexanone Catalyzed by Chiral Amidophosphine-Copper() TriflateIn refereedAcademic JournalCo-authorT. Mori;K. Kosaka;Y. Nakagawa;Y. Nagaoka;K. Tomioka;copper triflate;chiral amidophosphine;chnjugate addition;external chiral ligand;Tetrahedron Asymmetry1998~
PapersAsymmetrical membrane fluidity of bovine adrenal chromaffin cells and granules and effect of trichosporin-B-VlaIn refereedAcademic JournalCo-authorS. Kitagawa;E. Tachikawa;T. Kashimoto;Y. Nagaoka;A. Iida;T. Fujita;adrenal chromaffin cell;catecholamine;peptaibol;trichosporin;Biophys. Biochem. Acta.1998~
PapersSteric Tuning of Reactivity and Enantioselectivity in Addition of Thiophenol to , -Unsaturated Esters Mediated by a Chiral LigandIn refereedAcademic JournalCo-authorK. Nishimura;M. Ono;Y. Nagaoka;K. Tomioka;addition reaction;thiopenol;external chiral ligand;J. Am. Chem. Soc.1997~
PapersFungal Metabolites. XXI. Characteristics of Low Energy Collision Induced Dissociation of [M+2H]2+, [M+H+Na]2+ and [M+2Na]2+ of Peptaibols Using Electrospray Ionization Mass SpectrometryIn refereedAcademic JournalCo-authorM. Kanai;A. Iida;Y. Nagaoka;S. Wada;T.Fujita;mass spectrometry;electrospray;peptaibol;J. Mass Spectromet.1996~
PapersRole of Gln7 in the Ion-Channel-Forming Properties of a Peptaibol, Trichosporin-B-VlaIn refereedAcademic JournalCo-authorY. Nagaoka;A. Iida;T. Kambara;K. Asami;E. Tachikawa;T.Fujita;trichosporin;peptaibol;ion channel;J. Chem. Soc., Chem. Commun,1996~
PapersPathway for Ca2+ Influx into Cells by Trichosporin-B-IVa, An -Aminoisobutyric acid-containing Peptide, from the Fungus Trichoderma polysporum(##)In refereedAcademic JournalCo-authorE. Tachikawa;N. Nogimori;S. Takahashi;K. Mizuma;K. Itoh;T. Kashimoto;Y. Nagaoka;A.Iida;T.Fujita;trichosporin;ion channel;peptaibol;Biophys, Biochem, Acta,1996~
PapersRole of Proline Residue in the Channel-Forming and Catecholamine-Releasing Activities of the Peptaibol, Trichosporin-B-Vla(##)In refereedAcademic JournalCo-authorY. Nagaoka;A. Iida;T. Kambara;K. Asami;E. Tachikawa;T. Fujita;catecholamine;trichosporin;ion channel;peptaibol;Biophys. Biochem. Acta.1996~
PapersStructural Reguirements of an External, Chiral Amidophosphine Ligand for Asymmetric Reaction of an Organocopper Reagent(##)In refereedAcademic JournalCo-authorY. Nakagawa;M. Kanai;Y. Nagaoka;K. Tomioka;organo copper;external chiral ligand;chial amidophosphine;Tetrahedron Lett.1996~
PapersIon Channel Forming Properties of Antibiotic Peptides, Trichosporin-B-Vla and Its Derivatives, in Planar Lipid BilayersUnrefereedAcademic JournalCo-authorNAGAOKA Yasuo;peptaibol;trichosporin;antibiotic;ion channel;Peptide Chemistry 19941995~
PapersStructure Determination of Ion Channel Forming Peptides, Trichosporins, in a Complex Mixture by LC/ES-MSMSUnrefereedAcademic JournalCo-authorNAGAOKA Yasuo;peptaibol;trichosporin;antibiotic;ion channel;Peptide Chemistry 19941995~
PapersProperties of Trichosporin-B-Vla-Induced Catecholomine Secretion from Bovine Adrenal Chromaffin CellsIn refereedAcademic JournalCo-authorE. Tachikawa;S. Takahashi;K. Mizuma;T. Kashimoto;Y. Nagaoka;A. Iida;T. Fujita;trichosporin;peptaibol;catecholamine;Biol. Pharm. Bull.1995~
PapersFungal Metaboltes. XX. Effect of Proline Residue on the Structure of Ion-Channel-Forming Peptide, Trichosporin B-VIaIn refereedAcademic JournalCo-authorY. Nagaoka;A. Iida;E. Tachikawa;T. Fujita;trichosporin;peptaibol;ion channel;Chem. Pharm. Bull.1995~
PapersIon-channel-forming and Catecholamine-releasing Activities of Elongated and truncated Analogues of Trichosporin-BIn refereedAcademic JournalCo-authorY. Nagaoka;A. Iida;T. Kambara;K. Asami;T.Fujita;peptaibol;trichosporin;catecholamine;ion channel;J. Chem. Soc., Chem. Commun,1995~
PapersStructure and function of channel forming peptides. trichosporin-B-Vla and Aib14-trichosporin-B-Vla in lipid bilayers and biomembranesUnrefereedAcademic JournalNAGAOKA Yasuo;ion channel;peptaibol;trichosporin;Peptide Chemistry1994~
PapersSynthesis of 6-Methoxy-5,8-Quinolinediones and 8-Methoxy-5,6-Quinolinediones using Oxidative Demethylation with Cerium Ammonium NatrateIn refereedAcademic JournalCo-authorY. Kitahara;Y. Nagaoka;T. Matsumura;A. Kubo;oxidative demethylation;CAN;quinoline;Heterocycles1994~
PapersFungal Metabolites Part10. The Effect of Peptide Antibiotics, Trichosporin-Bs, on the Respiratory Activity of MitochondriaIn refereedAcademic JournalCo-authorM. Okuda;A. Iida;S. Uesato;Y. Nagaoka;T. Fujita;Y. Takaishi;H.Terada;mitochondria;peptaibol;trichosporin;Biol. Pharm. Bull.1994~
PapersFungal Metabolites. Part15. Primary Structures of Antibiotic peptides, Hypelcins B-I, B-II, B-III, B-IV, B-V, from Hypocrea peltataIn refereedAcademic JournalCo-authorNAGAOKA Yasuo;K. Matsauura;O. Shima;Y. Takeda;Y. Takaishi;Y.Nakaoka;T. Fujita;antibiotic;peptide;peptaibol;hypelcin;Chem. Pharm. Bull.1994~
PapersFungal Metabolites. Part17. Synthesis and NMR Study of Ion Channel-forming Peptides, Trichosporin B-Vla and Its Derivative.In refereedAcademic JournalCo-authorY. Nagaoka;A. Iida;T. Fujita;NMR;ion channel;peptaibol;trichosporin;Chem. Pharm. Bull.1994~
PapersFungal Metabolites. Part5, Rapid Structure Elucidation of Antibiotic Peptides, Minor Compornents of Trichosporin Bs from Trichoderma polysporumIn refereedAcademic JournalCo-authorJ. Iida;A. Iida;Y. Takahashi;Y. Takaishi;Y. Nagaoka;T. Fujita;Trichoderma;peptaibol;trichosporin;J. Chem. Soc. Parkin Trans. 11993~
PapersFungal Metabolites. Part6. Nuclear Magnetic Resonance Study of Antibiotic Peptides, Trichosporin Bs, from Trichoderma polysporumIn refereedAcademic JournalCo-authorA. Iida;S. Uesato;T. Shingu;M. Okuda;Y. Nagaoka;Y. Kuroda;T. Fujita;NMR;peptaibol;trichosporin;J. Chem. Soc. , Parkin Trans. 11993~
PapersFungal Metabolites. Part7, Solution Structure of an Antibiotic Peptide, Trichosporin B-V, from Trichoderma polysporumIn refereedAcademic JournalCo-authorA. Iida;S. Uesato;T. Shingu;Y. Nagaoka;Y. Kuroda;T. Fujita;NMR;peptaibol;trichosporin;J. Chem. Soc. , Parkin Trans, 11993~
PapersFungal Metabolites. Part9. Synthesis of Membrane-Modifying Peptide, Hypelcin A-III, from Hypocrea peltataIn refereedAcademic JournalCo-authorK. Matsuura;A. Yesilada;A. Iida;Y. Nagaoka;Y. Takaishi;T. Fujita;peptaibol;hypelcin;Chem. Pharm. Bull1993~
PapersStructure-Activity Relationships of Antibiotic Peptides which Cause Ca2+-Dependent Catecholamine ReleaseUnrefereedCo-authorNAGAOKA Yasuo;catecholamine;peptaibol;trichosporin;J. Pharmacobio-Dyn1992~
PapersTrichosporin--, an -Aminoisobutyric Acid-Containing Peptide, Causes Ca2+ -Dependent Catecholamine Secretion from Adrenal Medullary Chromaffin CellsIn refereedAcademic JournalCo-authorE. Tachikawa;S. Takahashi;K. Furumachi;T. Kashimoto;A.Iida;Y. Nagaoka;T.Fujita;Adrenal chromaffin cell;catecholamine;trichosporin;peptaibol;Molecular Pharmacology1991~
PapersIsolation and Structure-Activity Relationships of Antibiotic Peptides, Trichosporin-Bs, which Cause Ca2+-Dependent Cafecholamine Release from Adrenal Medullary Chromoffin CellsUnrefereedNAGAOKA Yasuo;catecholamine;peptaibol;trichosporin;J. Pharmacobio-Dyn1991~
PapersEffect of Lipophilicity of Trichosporin -Bs on Ion-Channel formation and Chatecholomene- Releasing ActivityIn refereedAcademic JournalCo-authorY. Nagaoka;A. Iida;T. Kambara;E. Tachikawa;K. Asami;T. Fujita;peptaibol;trichosporin;antibiotic;ion channel;Biol. Pharm. Bull.
Research Activities Overseas
- Kansai University's Overseas Research Program(long term)2005-2006
Participation in International Conferences
- 224th ACS National Meeting Aug.2002
- 230th ACS National Meeting Aug.28,2005-Sep. 1,2005
- 43JPS/PEM4 2006
- Collaboration between ASEAN Countries in Environment and Life Sciences 2007
- ICPH2007 3rd International Conference on Polyphenols and Health 2007
Courses Taught
- Chemistry (Fundamental Organic Chemistry I)
- Freshmen Seminar
- Fundamental Experiments of Life Science
- Instrumental Analysis
- Exercises in Thesis Projects I and II
- Thesis Projects I
- Thesis Projects II
- Science and Technology English I
- Law Related to Food and Pharmaceutical Affairs
- Sponsored Lecture (Beauty & Cosmetic Industry)
- SeminarI(Biotechnology)
- SeminarII(Biotechnology)
- SeminarIII(Biotechnology)
- SeminarIV(Biotechnology)
- Advanced Pharmacological Action of Medicines
- SeminarVI(Biotechnology)
- SeminarV(Biotechnology)
- Advanced Pharmacological Action of Medicines
- Personal Information
- Research Activities
- Research Activities
- Community Service
- Courses Taught